{"id":281946,"date":"2020-11-01T05:42:03","date_gmt":"2020-11-01T10:42:03","guid":{"rendered":"https:\/\/www.rael.org\/?p=281946"},"modified":"2020-11-10T20:30:30","modified_gmt":"2020-11-11T01:30:30","slug":"scientists-discover-devastating-new-genetic-disease-thats-killed-40-of-known-patients-by-attacking-lungs-and-immune-system","status":"publish","type":"post","link":"https:\/\/noproxy.rael.org\/bg\/scientists-discover-devastating-new-genetic-disease-thats-killed-40-of-known-patients-by-attacking-lungs-and-immune-system\/","title":{"rendered":"Scientists discover \u2018devastating\u2019 NEW genetic disease that\u2019s killed 40% of known patients by attacking lungs and immune system"},"content":{"rendered":"<h5><span style=\"color: #008080\"><strong>RAEL&#8217;S COMMENT:<\/strong><\/span><\/h5>\n<h5><span style=\"color: #008080\"><strong>And there are (always have been and will be) many more! That&#8217;s called: life.<\/strong><\/span><\/h5>\n<p>&nbsp;<\/p>\n<p><!--more--><\/p>\n<p>The new condition, which is caused by genetic mutations, has shown a particularly high death rate, as patients were not responding to any currently available treatments, the researchers said.<\/p>\n<p>The disease \u2013 \u2018vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome\u2019 \u2013 has been dubbed VEXAS. It causes symptoms that include blood clots in veins, recurrent fevers, abnormalities in the lungs, and vacuoles \u2013 unusual cavity-like structures \u2013 in the myeloid cells, which play a crucial part in the human immune system.<\/p>\n<p>Researchers at the US National Institutes of Health (NIH) came across the disease after analyzing the genome sequences of more than 2,500 people with undiagnosed inflammatory diseases. In comparing the data, they found that 25 adult males had particular mutations in the UBA1 gene, which is believed to be the source of VEXAS.<\/p>\n<p>\u201cInstead of looking at clinical similarities, we were instead taking advantage of shared genomic similarities that could help us discover a completely new disease,\u201d\u00a0said Daniel Kastner, the scientific director of the Intramural Research Program at the National Human Genome Research Institute.<\/p>\n<p>The NIH reported that the new disease\u00a0\u201ccan be life-threatening,\u201d\u00a0as 40 percent of the VEXAS patients the researchers studied have died. The high death toll revealed\u00a0\u201cthe devastating consequences of the severe condition,\u201d\u00a0the team stated.<\/p>\n<p>Kastner told NBC News that patients with VEXAS become\u00a0\u201creally sick,\u201d\u00a0and\u00a0\u201cdon\u2019t respond to any treatments, from high doses of steroids to various chemotherapies.\u201d<\/p>\n<p><a href=\"https:\/\/www.rt.com\/news\/505179-new-disease-lungs-immune\/?fbclid=IwAR38A6XjEyCYceIKwPz1aNhgSYjZ2FIfMIcaLMLdfeRQbvJSDFzOAhGhMDg\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #0000ff\">https:\/\/www.rt.com\/news\/505179-new-disease-lungs-immune\/?fbclid=IwAR38A6XjEyCYceIKwPz1aNhgSYjZ2FIfMIcaLMLdfeRQbvJSDFzOAhGhMDg<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>RAEL&#8217;S COMMENT: And there are (always have been and will be) many more! That&#8217;s called: life. &nbsp;<\/p>\n","protected":false},"author":71,"featured_media":281947,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-281946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/posts\/281946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/users\/71"}],"replies":[{"embeddable":true,"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/comments?post=281946"}],"version-history":[{"count":0,"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/posts\/281946\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/media\/281947"}],"wp:attachment":[{"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/media?parent=281946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/categories?post=281946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/noproxy.rael.org\/bg\/wp-json\/wp\/v2\/tags?post=281946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}